The effects of crystal meth on the liver and kidney function parameters of wistar albino rats

The aim of this research is to evaluate the effects of administering crystal meth via oral, nasal and intraperitoneal routes on the liver function and renal toxicity parameters using wistar rats. A total of 35 wistar rats were split into 7 groups and administered two doses of the sample (40 and 1000mg/70kg) via 3 different routes for 21days. The animals were weighed 4 times before sacrifice and biochemical analysis. The group orally administered 1000mg/70kg showed the highest percentage reduction in weight 24.4% compared to day 1. The ALP and ALT levels showed significant elevations across all groups when compared to control. However, the group intraperitoneally administered 1000mg/70kg showed the highest increase in ALP activity levels when compared to control while the highest increase in AST activity levels were recorded in groups orally administered 1000mg/70kg. The total protein, serum creatinine and AST levels showed no significant fluctuations. The highest recorded increase in blood urea and serum creatinine levels were recorded in the group intraperitoneally administered 1000mg/70kg. The result showed that crystal meth increased the renal toxicity parameters and some liver function parameters especially in high doses, therefore can cause major damage to either or both organs if exposure prolonged.