Effect of tamoxifen on serum lipid profile in female albino rats

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Author: 
Taha Shawi Morad, Ammal Esmaeel Ibrahim and Shatha Mahmood Hasan
Abstract: 

Tamoxifen is a sold under the brand name Nolvadex among others, is a medicine that is used to inhibit breast cancer in women and treat breast cancer in men and women. It is also being studied for other types of cancer. The study included 36 female albino rats divided to three groups the group A include 12 female albino rats whom treated with 20 mg of Tamoxifen for 60 days, group (B) which include 12 female albino rats weight (180-210) g aged (5-6) month whom treated with 20 mg of Tamoxifen for 90 days and control group (group C) which include 12 female albino rats. The results show that Tamoxifen can effect on lipid metabolism by increase the level of HDL and Reduce the level of total cholesterol and LDL. In ConclusionTamoxifen have cardio-protective effects on lipid metabolism.

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