Introduction: Marriages between blood relatives are nowadays cultural norms & are least researched in relation to adverse child health outcomes. The fetal growth ratio can be used to demonstrate this effect.
Objective: To determine the effect of consanguinity on fetal growth ratio.
Methods: Cross-sectional data was collected through filling of pre designed questionnaire on three hundred & fifty six consecutive live born singleton newborns delivered in various hospitals in Hyderabad in September 2015. Birth weight was modeled by use of fetal growth ratio & its association with parental inbreeding was analyzed by logistic regression analysis.
Results: Consanguinity was found among 55.4% subjects. The mean growth ratio in consanguineous group was 0.861 ± 0.085 versus 0.941 ± 0.06 among non-consanguineous. The corresponding values for parents inbred & non-inbred were found as 0.859 ± 0.074 & 0.861 ± 0.104 respectively. The logistic regression analysis to predict net effect of inbreeding on fetal growth ratio after controlling for medical and socio-demographic covariates, revealed a statistically significant negative association between parental inbreeding and fetal growth ratio (OR 1.48; 95% C.I 1.033 - 1.591; p=0.04).
Conclusions: Parental inbreeding affects the birth weight of new borne at corresponding age of gestation.
Prof. Dr. Bilal BİLGİN