The dependence of proton related acidity inside erythrocytes from the proton conductance in the previous 8 stages of the full 9 stepped cycle of proton conductance

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Author: 
Ambaga, M.
Abstract: 

It is established that in case of changing of electrons and protons normal conductance by uncoupler as rotenone - inhibitor of mitochondrial respiratory chain complex I, inhibitor of mitochondrial hydrogen atom transport at NADH: ubiquinone oxidoreductase level, the significance of the pH value in the outside of isolated erythrocytes, the significance of the pH value after the partial hemolysis of isolated erythrocytes, the significance of the pH value after the full hemolysis of isolated erythrocytes changed to alkaline side. Under effect of uncoupler rotenone, which action occured in the 2-th stage of the full 9 stepped cycle of proton conductance inside human body in the form of blockage of transferring of proton, electron to NADH, FADH2 as hydrogen atom accompanying with release of CO2, the significance of the pH value have been changed to alkaline side i.e. blockage of the transferring of protons and electrons to NADH as hydrogen atom lead to decrease of free proton concentration, proton related acidity inside erythrocyte membrane surroundings. Meanwhile, in case of changing of electrons and protons normal conductance by uncoupler as dinitrophenol - proton ionophore, the significance of the pH value in the outside of isolated erythrocytes, the significance of the pH value after the partial hemolysis of isolated erythrocytes, the significance of the pH value after the full hemolysis of of isolated erythrocytes under uncoupler effect of dinitrophenol, which action occured in the 6-th stage of the full 9 stepped cycle of proton conductance inside human body, when is occured the processes as shuttle protons (hydrogen cations) across membranes, dissipated the proton gradient across mitochondria, the energy of the proton gradient less converted to producing ATP, lost as heat, changed to acidic side i.e. dissipation of the proton gradient across mitochondria lead to increase of free proton concentration, proton related acidity inside erythrocyte membrane surroundings. Meanwhile, in case of changing of electrons and protons normal conductance by uncoupler as oligomycin, the significance of the pH value in the outside of isolated erythrocytes, the significance of the pH value after the partial hemolysis of isolated erythrocytes, the significance of the pH value after the full hemolysis of of isolated erythrocytes under effect of uncoupler dinitrophenol, which action occured in the 6 - th stage of the full 9 stepped cycle of proton conductance inside human body as the inhibition of ATP synthase by blocking its proton channel (Fo subunit), reducing of proton flow to mitochondria matrix, changed to alkaline side i.e. inhibition of ATP synthase by blocking its proton channel (Fo subunit), reducing of proton flow to mitochondria matrix lead to decrease of free proton concentration, proton related acidity inside erythrocyte membrane surroundings.

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