Coagulation profile in sudanese pediatric leukemic patients

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Author: 
Eihab Idris Mohammed, Babikr Ahmed Mohamed, Fath Elrahman Mahdi Hassan Gameel and Mansoor Mohammed Mansoor
Abstract: 

Aim: we conducted our study to evaluate coagulation profile in Sudanese Pediatric Patients with leukemia.
Materials and methods: This study is a prospective analytical case control study was conducted to evaluate coagulation profile in 97 Sudanese pediatric patients with leukemia; the population comprises all male and female pediatric patients, during the period of collection (2014-2015) admitted in Khartoum Radiation and Isotopes Centre, 98 individual pediatric (0 – 15 years) male and female apparently healthy from primary, Kindergartens and nurseries schools are selected as control group.
Results: In case group gender wise males are 52(53.1%) and females are 46(46.9%) with mean age for all 9.03 years. The case group in our study was divided into three subgroups based on type of leukemia ALL was 81(82.7%), AML 12(12.2%) and CML 5 (5.1%). There is significant correlation between case and control group in PT, PTT, Platelets and Protein C (P values < 0.05) (Table 3). There are only two patients which there D-dimmer level were more than 200 ng/ml (high) and all control group and other patient were normal (< 200 ng/ml).
Conclusion: We conclude that there were significant variations in PT, PTT, Protein C, Fibrinogen level and Platelet count between case and control group.

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