Clinical characteristics of multidrug-resistant escherichia coli at a tertiary care university hospital in Japan

Masaaki Minami, Naoki Wakiyama, Minoru Ohashi, Yukio Wakimoto and Michio Ohta

Escherichia coli is the leading cause of various infectious diseases such as pneumonia, urinary tract and blood stream infections. Furthermore the emergenceof multidrug-resistant Escherichia coli has been focused worldwide. The objective of this study was to determine the clinical characteristics of multidrug-resistant Escherichia coli at a tertiary care university hospital in the central region of Japan. We determined the in vitro susceptibilities of 10 antimicrobial agents for 530 multidrug-resistant Escherichia coli in Japan. From antimicrobial susceptible results, these results indicated the over 60% of multidrug-resistant Escherichia coli had beta lactamase and fluoroquinolone resistant ability. Our results also revealed that the risk factors of multidrug-resistant Escherichiacoli were over 60 years, and department of urology. The emergence of multi-drug resistant Escherichia coli suggests that further aggressive surveillance is needed for providing useful information on the trends in antimicrobial resistance

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