Chemotherapeutic effect of celery seed oil against hepatocellular carcinoma induced by diethylnitrosamine in rats

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Author: 
Omaima A.M. Ahmedy, Mostafa E. El-sayed, Afaf A. Shoka, Hekma A. Abd El-Latif, Ashraf K. Bahgat, Somaya Z. Mansour and Azza Hassan
Abstract: 

Background: Hepatocellular carcinoma (HCC) is one of the world’s deadliest cancers and considered as the second main cause of cancer-related mortalities. Therefore, the discovery of effective and safe drugs for chemoprevention and treatment of HCC is of great importance. This study aimed to investigate the potential anticancer activity of celery seed oil (CSO).The serum tumour marker AFP and liver enzymes ALT, AST, γ-GT,ALP, TB,as well as final body weight and liver index are valuable references, widely used in animal studies to diagnose and monitor the development of hepatocarcinogenesis. In the present study, the values of previously mentioned parameters showed sharp increase in diethylnitrosamine (DENA) group as compared with that of the normal control group. Additionally, DENA increased the hepatic expression of the tumour marker hepPar-1 that was immunohistochemically investigated. Moreover, these DENA-induced changes were confirmed histopathologically.CSO treatment significantly decreased the DENA-induced elevated transaminases, γ-GT, AFP, diminished the elevated hepatic expression of hepPar-1and ameliorated the DENA-induced neoplastic changes histopathologically. However, final body weight, liver index, ALP and TB were improved but did not reach significance. Moreover, the biochemical analysis of hepatic tissues further demonstrated that CSO counteracts DENA-induced oxidative stress through the reduction of MDA and the restoration of antioxidant enzyme catalase. In conclusion, CSO possesses chemotherapeutic activity against HCC in rats which are probably mediated through antioxidant mechanism. Furthermore, CSO can be envisaged for further investigation in efforts to understand the precise mechanism of cytotoxity.

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