Cafeteria diet and obesity: mutagenicity in wistar rats and consequences on female offspring

International Journal of Development Research

Volume: 
7
Article ID: 
10584
4 pages
Research Article

Cafeteria diet and obesity: mutagenicity in wistar rats and consequences on female offspring

Bárbara Zenardini, Maruhen Amir Datsch Silveira, Sara Cristina Sagae and Luciana Paula Grégio d'Arce

Abstract: 

Besides genetic factors, diet components may contribute to the development of obesity, and it is known that cafeteria diet is characterized by a high caloric intake. Thus, the present study evaluated the mutagenic effects that cafeteria diet exerted on Wistar rats and its consequences on female offspring. Twelve females (generation 1) were separated in control group (CTL) and Cafeteria Diet group (CAF). At 70 days of age, females were mated with non-obese control males. Weaning at 21 days of age, female offspring (2nd generation) were separated into daughters of CTL or CAF mothers and subdivided according to previous diet. Ratio of polychromatic erythrocytes (PCE) / normochromatic erythrocytes (NCE) in a total of 1000 cells and Micronuclei (MN) 1000 PCE were evaluated. Were observed high MN frequencies, body weight, retroperitoneal and perigonadal fat; and low PCE/NCE ratio in generation 1. In generation 2, cafeteria diet caused high body weight, retroperitoneal and perigonadal fat and perpetuation of cytotoxicity in offspring, regardless of the cafeteria diet. Changing the diet of offspring, no statistically differences were observed in MN frequencies, PCE/NCE ratio, body weight and retroperitoneal fat, showing the importance of diet even with a disadvantageous mother background.

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