Bone remodeling biomarkers rankl, opg and cathepsin k levels in periodontal disease patients: a systematic review
International Journal of Development Research
Bone remodeling biomarkers rankl, opg and cathepsin k levels in periodontal disease patients: a systematic review
Received 17th January, 2020; Received in revised form 20th February, 2020; Accepted 26th March, 2020; Published online 30th April, 2020
Copyright © 2020, Everton Freitas de Morais et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Objective: The aim of this systematic review was to evaluate biomarkers associated to the bone remodeling process in periodontal disease patients through the evaluation of oral fluids, assessing their validity as possible biomarkers in periodontal diseasediagnosis and progression. Method and Materials: A systematic search at the PubMed/Medline, CENTRAL (The Cochrane Library), EMBASE and Web of Science databases was performed: Studies involving the analysis of biomarkers associated to the bone resorption process in salivary fluid (SF) and gingival crevicular fluid (GCF) in patients diagnosed with periodontal disease evaluating their effectiveness as periodontal diseasebiomarkers were selected. Results: Twelve articles published between 2004 and 2017 met all the inclusion criteria and were selected for the systematic review. The selected studies demonstrated significantly higher RANKL and Cathepsin-K concentrations and decreased OPG levels in periodontal diseasepatients compared to controls, as well as in patients in more advanced periodontal diseasestages. Conclusion: In conclusion, the present study points out the potential use of biomarkers related to bone remodeling in patients diagnosed with periodontal diseasethrough GCF and SF analyses.
