The biological significance of released protons from erythrocyte membrane surroundings within the full 9 stepped cycle of proton conductance

The explanation of biological significance of released protons from erythrocyte membrane surroundings within in the full 9 stepped cycle of proton conductance is one of very interesting aspects of Modern medicine. By our suggestion, the biological significance of released protons from erythrocyte membrane surroundings within in the full 9 stepped cycle of proton conductance have been appeared as participation of protons by including in the composition of H2CO3 (carbonic acid) and bicarbonate ions in the synthesis of gastric HCL and in the synthesis of bicarbonate ions of pancreatic duct cell, also in the kidney regulation of proton dependent acid – base balance and in the respiratory regulation of proton dependent acid – base balance. In such way may be say that HCO3 (bicarbonate ions) and hydrogen ions (proton) are derived from carbon dioxide and water molecules, which formed within the full cycle of proton conductance, which conducted as follows as the second stage, where formed CO2 and the seventh stage, where formed metabolic water - H2O in the result of oxidation of protons by activated oxygens. Carbon dioxide and water, which enter to all cells have contained protons released from food substrates and repackaged in the erythrocyte membrane surroundings, released from this. Beside all this, protons released from erythrocyte membrane surroundings by incorporating in to composition of HCO3 (bicarbonate ions) have been participated in the biosynthesis of pyrimidine ribonucleotides, which have been conducted as ATP + HCO3 + glutamine + H2O = carbamoyl phosphate, carbomoylphosphate + aspartate = carbamoyl aspartate, carbamoyl aspartate = H2O + dihydroorotate, dihydroorotate + quinine = orotate, orotate + PRPP = orotidine monophosphate (OMP), OMP = CO2 + uridine monophosphate (UMP).