Biochemical changes of liver enzymes among type 2 diabetic patients at wad medani, medical diabetic centre – Medani City - Gezira State- Sudan

Objective: The study aimed to evaluate some biochemical changes of the liver enzymes in patients with diabetes mellitus type 2 to measured aspartate aminotransferase, and alanine aminotransferase enzymes. Methods: The study was carried out using fifty blood samples collected from Medical Diabetic Center in Medani, between 1. July to September 2018. Samples collected in heparinized tubes and were centrifuged for unhemolyzed serum collection for assessment of liver enzymes, alanine aminotransferase enzymes & aspartate aminotransferase. The principle of ALT was determined by enzymatic kinetic methods using ALT estimation kit (Biosystem). This ALT method was based on transfers the amino group from alanine to 2- Oxoglutarate to form pyruvate and glutamate. Results: The study revealed that the fasting blood glucose increased in 43 patients, which represents 86%. Aspartate aminotransferase increased in 4 patients, which represents 8%. Alanine aminotransferase increased in 4 patients, which represents 8%. Conclusion: The overall of this study, indicated that the (8) of patients, which represents 16%, had at least some changes of abnormal one or both liver enzymes in type 2 diabetes mellitus in patients on hypoglycemic agents.