Biochemical and histological evaluation of the inflammatory response to barbed polydioxanone and polyglacting 910 in vaginal apex and abdominal aponeurosis suture in pigs submitted to hysterectomy

The number of women submitted to hysterectomy grows every year. Such procedure can be carried out using different techniques regarding access, type of suture and the surgical thread used. Surgical threads play a relevant role in surgical practice and there is a great variety of materials with which they are produced. Therefore, they enable the use of different suture techniques, minimizing the tissue reaction and reducing the time needed for this procedure. This study aimed to demonstrate that both threads have similar characteristics and, therefore, we can suggest the use of Stratafix® for procedures that minimize surgical time is relevant (laparoscopic video surgeries, for example). This study carried out 16 abdominal hysterectomies in pigs, divided into two groups, eight using polydioxanone thread (Stratafix®) and the other eight using polyglactin 910 thread (Vicryl®). Blood samples were collected before the surgery, (D1) and in the collection of aponeurosis and vaginal Apex samples (D9). The blood samples, (D1 and D9) were submitted to the following examinations: Complete blood count andfibrinogen and C reactive protein measurement, to evaluate systemic inflammatory reaction. When the aponeurosis and vaginal apex samples (D9) were collected, the presence or absence of local adherences or abscesses was observed, and then the material was sent to histological analysis, for the evaluation of fibrosis and fat encapsulation, Classification and attribution of indices to the histological findings and later characterization of the inflammatory process phase. In this study, we did not observe significant changes in the data analyzed in relation to both types of thread investigated.