THE BASIC KNOWLEDGES ABOUT THE POSSIBILTY OF EMPLOY THE MICRONUCLEUS TEST FOR THE DIAGNOSIS OF THE DOUBTH CASES IN THE SCREENING FOR THE DETERMINATION OF BREAST CANCER

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Author: 
Menicagli, R. and Menicagli, L.
Abstract: 

Introduction and Objectives: The aim of this study is to check the possibility to use the tests with micronuclei in saliva for cases doubts detected in screening for breast cancer
Material and Methods: The principal search on Pub Med (MEDLINE), Home Genetic Reference is for articles published from Jan 1, 2000 to Dec 31, 2001,for the keywords : "micronuclei in exfoliated buccal cells in breast cancer “ The key words are used in the research in free text, and with cross –referencing method application. Another search it is been made for “MN in breast cancer “, from Jan1 2014 to today.
Results: Five studies show that in buccal cells, in breast cancer the MN are significantly higher than compared to benign cases as in six studies for the detection of micronuclei in needle aspirates ductal,. Contrasting results are for MN in peripheral blood lymphocytes
Discussion: The micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast cancer while the tests in peripheral blood lymphocytes , have known reproducibility problems .The exfoliated buccal mucosa cells test, show an increase of MN. May be interesting to apply the MN scoring in cases of doubt, according to functional BI-RADS category 3 (probably benign), and which are sent to a control
Conclusions: it has verified that in buccal cells, in cases of breast cancer is significantly higher than the number of MN compared to benign cases, indicates the possibility of applying this technique in cases of doubt, in oral saliva.

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