Application of solvent injection method to develop stable, sustained release solid lipid Nanoparticles of Curcumin

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International Journal of Development Research

Application of solvent injection method to develop stable, sustained release solid lipid Nanoparticles of Curcumin

Abstract: 

Curcumin has a wide spectrum of biological and pharmacological activities such as anti- inflammatory and anti-cancer activities but its main drawbacks (poor bioavailability and rapid metabolism) have restricted its therapeutic applications. The main strategies used to overcome the physicochemical limitations of curcumin in order to improve its bioavailability are based on loading the compound in nanocarriers, such as liposomes, cyclodextrins and solid lipids. Therefore, the purpose of this study was to formulate Solid lipid nanoparticles of curcumin (CSLNs) to overcome its drawbacks. Simple, effective and versatile method (Solvent Injection Method or SIM) was used to prepare the CSLNs. The physicochemical properties of CSLNs formula were investigated as well as the in-vitro release study. The prepared formula showed a mean particle size of 249 nm with Polydispersity Index (PdI) value of 0.185, Zeta Potential value of -31.81 mV and 74.51 % Entrapment Efficiency (EE%). The conducted Differential Scanning Calorimetry (DSC) analysis revealed the amorphous nature of the encapsulated curcumin. The release profile of curcumin showed a sustained release mode after an initial burst following Higuchi diffusion model. The conducted stability methods showed that the prepared CSLN formula was physically and chemically stable. These observations implied that CSLNs formulation could be a promising candidate that can be used in treatment of various diseases.

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